[fChk]

So, that's the established facts -so far- and I'm really open-minded as to an eventual treatment effect on COVID-19, but we need more data!..

I came across this US-NIH note about Ivermectin on its COVID-19 Treatment Guidelines

In the section on 'Proposed Mechanism of Action and Rationale for Use in Patients With COVID-19':

Reports from in vitro studies suggest that ivermectin acts by inhibiting the host importin alpha/beta-1 nuclear transport proteins, which are part of a key intracellular transport process that viruses hijack to enhance infection by suppressing the host’s antiviral response.4,5 In addition, ivermectin docking may interfere with the attachment of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein to the human cell membrane.6 Ivermectin is thought to be a host-directed agent, which may be the basis for its broad-spectrum activity in vitro against the viruses that cause dengue, Zika, HIV, and yellow fever.4,7-9 Despite this in vitro activity, no clinical trials have reported a clinical benefit for ivermectin in patients with these viruses. Some studies of ivermectin have also reported potential anti-inflammatory properties, which have been postulated to be beneficial in people with COVID-19.10-12

There you have it!.. The rationale for a potential antiviral activity in-vitro has been demonstrated but the problem remains as to how to translate that effect with the needed doses that are beyond what's clinically allowed in Humans!.. Ivermectin neurotoxicity -see my previous post here- is hard to ignore!

So US-NIH's recomendation is this:

There are insufficient data for the COVID-19 Treatment Guidelines Panel (the Panel) to recommend either for or against the use of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin in the treatment of COVID-19.